Vol 3-5 Review Article

Stented Porcine and Pericardial Bioprostheses - A historical review

Andrea De Martino1, Giosuè Falcetta1, Aldo D. Milano2, Uberto Bortolotti1*

1Cardiovascular Surgery Divisions, University of Pisa, Italy

2Department of Cardiac Surgery, University of Bari Aldo Moro, Bari, Italy

Stented bioprostheses have been extensively used clinically to replace diseased cardiac valves with the clear advantage over mechanical prostheses of avoiding the use of chronic anticoagulation in most cases. During the past five decades, however, based on clinical and pathological experience, tissue calcification and cusp tears were identified as the main determinants of failure of porcine and pericardial bioprostheses, respectively. Tissue treatments to mitigate dystrophic calcification together with structural modifications in valve design have produced a current generation of bioprosthetic valves which show excellent overall performance and considerably increased durability when compared with old models. Further ongoing research aims to provide even more durable bioprostheses in order to allow reduction of the age threshold for implantation also in younger subjects, helping to contrast effectively the rapidly expanding role of catheter-based interventions.

DOI: 10.29245/2578-3025/2019/5.1179 View / Download Pdf
Vol 3-5 Review Article

Long Non-Coding RNAs: Crucial Players of Cardiomyocyte Apoptosis

Xiatian Chen1,2, Ziqian Liu1,2, Zhe Li1,2, Jinning Gao1,2, Zhongjie Yu1,2, Peifeng Li1*, Lynn Htet Htet Aung1#

1Center for Molecular Genetics, Institute for Translational Medicine, Qingdao University, Qingdao, 266000, Shandong, China

2School of Basic Medicine, Qingdao University, Qingdao, 266000, Shandong, China

Long non-coding RNAs (lncRNAs) have gained more attention in recent years as a potential new regulator of nearly all biological regulation. LncRNAs are over 200 nucleotides in length, and it can interact with other non-coding RNAs or specific proteins to influence the gene expression. Cardiomyocyte apoptosis is associated with cardiovascular diseases. Accumulating studies have uncovered novel lncRNAs-mediated regulation of cardiovascular diseases; however, the knowledge of the mechanisms by how to act is still limited. This review highlights the role of lncRNAs involved in cardiomyocyte apoptosis with a focus on the regulatory axis. These examples may provide helpful insights on how lncRNAs interfere with cardiomyocyte apoptosis.

DOI: 10.29245/2578-3025/2019/5.1178 View / Download Pdf