Vol 5-1 Original Research Article

Clinical Characteristics of Cardiac and Pericardial Metastasis in Small Cell Lung Cancer with Arrhythmia

Yuling He1, Jingjing Wang1, Lingdong Kong1, Bo Jia1, Yujia Chi1, Xiaoyu Zhai1, Han Jin2, Ziping Wang1*

1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Thoracic Medical Oncology, Peking University Cancer Hospital and Institute, China

2Department of Cardiology, Peking University First Hospital, China

Background: Cardiac and pericardial metastasis in small cell lung cancer (SCLC) is more common than estimated, but there are a few related studies in the literature. This study aims to raise the attention of such clinical circumstances.

Methods: We analyzed the clinical data of 62 SCLC patients with arrhythmia and confirmed eleven cases of SCLC with cardiac and/or pericardial metastasis by cytology or imaging diagnosis. Survival analysis was performed by the Kaplan-Meier method.

Results: Among 11 patients, 6 had pericardial involvement, 10 had mediastinal lymph node metastasis, and 8 had hilar lymph node metastasis. The most common type of electrocardiogram (ECG) abnormality was supraventricular arrhythmias (10/11). Complete imaging data were obtained in 7 patients through whole treatment after diagnosed with cardiac metastasis. Among them, 5 patients achieved partial response, and 2 of them achieved improvements in ECG abnormality. In the two remaining patients, advances in imaging diagnosis were identified after treatment, and new abnormalities were found in their ECG. The median overall survival time of the 11 patients was 11 months.

Conclusions: Cardiac and pericardial metastasis of SCLC can present different types of arrhythmia, and the ECG may change after treatment. Clinicians should take this condition into consideration, and aggressive treatment may achieve significant remission. 

DOI: 10.29245/2578-3025/2021/1.1211 View / Download Pdf
Vol 5-1 Commentary

Commentary: The Effects of Different Fluorescent Indicators in Observing the Changes of The Mitochondrial Membrane Potential During Oxidative Stress-Induced Mitochondrial Injury of Cardiac H9c2 Cells

Yanyi Tian1,4,5, Wei Tian2,4,5, Ting Li3, Jingman Xu1,4,5*

1Heart Institute, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China

2Analysis and Test Center, North China University of Science and Technology, Tangshan, Hebei, China

3College of Foreign Language, North China University of Science and Technology, Tangshan, Hebei, China

4Hebei Province Key Laboratory of Organ Fibrosis, Tangshan, Hebei, China

5International Scientific and Technological Cooperation Base of Geriatrics Medicine, Tangshan, Hebei, China

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Vol 5-1 Commentary

Commentary: Description of the Position and Performance of an Echocardiogram by Subcostal View During the Prone Position in A Patient with Severe Pneumonia Caused by COVID-19

César Del Castillo Gordillo1,2*, Mario Alfaro Diaz1

1Cardiovascular center, San Borja Arriaran Hospital, Santiago, Chile

2Cardiovascular center, DIPRECA Hospital, Santiago, Chile

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