Clinical Characteristics of Cardiac and Pericardial Metastasis in Small Cell Lung Cancer with Arrhythmia
Yuling He1, Jingjing Wang1, Lingdong Kong1, Bo Jia1, Yujia Chi1, Xiaoyu Zhai1, Han Jin2, Ziping Wang1*
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Thoracic Medical Oncology, Peking University Cancer Hospital and Institute, China
2Department of Cardiology, Peking University First Hospital, China
Background: Cardiac and pericardial metastasis in small cell lung cancer (SCLC) is more common than estimated, but there are a few related studies in the literature. This study aims to raise the attention of such clinical circumstances.
Methods: We analyzed the clinical data of 62 SCLC patients with arrhythmia and confirmed eleven cases of SCLC with cardiac and/or pericardial metastasis by cytology or imaging diagnosis. Survival analysis was performed by the Kaplan-Meier method.
Results: Among 11 patients, 6 had pericardial involvement, 10 had mediastinal lymph node metastasis, and 8 had hilar lymph node metastasis. The most common type of electrocardiogram (ECG) abnormality was supraventricular arrhythmias (10/11). Complete imaging data were obtained in 7 patients through whole treatment after diagnosed with cardiac metastasis. Among them, 5 patients achieved partial response, and 2 of them achieved improvements in ECG abnormality. In the two remaining patients, advances in imaging diagnosis were identified after treatment, and new abnormalities were found in their ECG. The median overall survival time of the 11 patients was 11 months.
Conclusions: Cardiac and pericardial metastasis of SCLC can present different types of arrhythmia, and the ECG may change after treatment. Clinicians should take this condition into consideration, and aggressive treatment may achieve significant remission.DOI: 10.29245/2578-3025/2021/1.1211 View / Download Pdf
Commentary: The Effects of Different Fluorescent Indicators in Observing the Changes of The Mitochondrial Membrane Potential During Oxidative Stress-Induced Mitochondrial Injury of Cardiac H9c2 Cells
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Yanyi Tian1,4,5, Wei Tian2,4,5, Ting Li3, Jingman Xu1,4,5*
1Heart Institute, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China
2Analysis and Test Center, North China University of Science and Technology, Tangshan, Hebei, China
3College of Foreign Language, North China University of Science and Technology, Tangshan, Hebei, China
4Hebei Province Key Laboratory of Organ Fibrosis, Tangshan, Hebei, China
5International Scientific and Technological Cooperation Base of Geriatrics Medicine, Tangshan, Hebei, China
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César Del Castillo Gordillo1,2*, Mario Alfaro Diaz1
1Cardiovascular center, San Borja Arriaran Hospital, Santiago, Chile
2Cardiovascular center, DIPRECA Hospital, Santiago, Chile